Lometrexol hydrate
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Lometrexol hydrate

SKU T41297-25 mg Category Brand:

Price range: 3,680 CAD through 4,784 CAD

Products Details

Product Description

– Lometrexol hydrate (DDATHF hydrate) is an antipurine antifolate compound that inhibits glycinamide ribonucleotide formyltransferase (GARFT) activity without inducing detectable DNA strand breaks. It further disrupts de novo purine synthesis, leading to abnormal cell proliferation, apoptosis, and cell cycle arrest, exhibiting anticancer activity [1] [2]. Additionally, it acts as a potent inhibitor of human Serine hydroxymethyltransferase1/2 (h SHMT1/2) [3].

Web ID

– T41297

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C21H27N5O7

CAS Number

– 1435784-14-7

Molecular Weight

– C21H27N5O7

SMILES

– O.Nc1nc2NC[C@H](CCc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)Cc2c(=O)[nH]1

Pathway

– Others

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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