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Lithocholic acid
$55 – $106
Products Details
Product Description
– Lithocholic acid is a toxic secondary bile acid that can promote intrahepatic cholestasis and promote tumorigenesis. Lithocholic acid is also a FXR antagonist and a PXR/SXR agonist[1][2][3][4][5].
Web ID
– HY-B0172
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Metabolism-sugar/lipid metabolism
Molecular Formula
– C24H40O3
References
– [1]Yang R, et al. Metabolomic analysis of cholestatic liver damage in mice. Food Chem Toxicol. 2018 Jul 14;120:253-260.|[2]Jenkins, D.J., et al., Effect on blood lipids of very high intakes of fiber in diets low in saturated fat and cholesterol. N Engl J Med, 1993. 329(1): p. 21-6.|[3]Goldberg, A.A., et al., Lithocholic bile acid selectively kills neuroblastoma cells, while sparing normal neuronal cells. Oncotarget, 2011. 2(10): p. 761-82.|[4]Matsubara, T., et al., TGF-beta-SMAD3 signaling mediates hepatic bile acid and phospholipid metabolism following lithocholic acid-induced liver injury. J Lipid Res, 2012. 53(12): p. 2698-707.|[5]Yu J, et al. Lithocholic acid decreases expression of bile salt export pump through farnesoid X receptor antagonist activity. J Biol Chem. 2002 Aug 30;277(35):31441-7.
CAS Number
– 434-13-9
Molecular Weight
– 376.57
Compound Purity
– 98.0
SMILES
– C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCC(O)=O)([H])[C@@]3([H])[C@]([C@@]4([C@](C[C@H](O)CC4)([H])CC3)C)([H])CC1
Clinical Information
– No Development Reported
Research Area
– Cancer; Metabolic Disease
Solubility
– DMSO : 250 mg/mL (ultrasonic)|Ethanol : 10 mg/mL (ultrasonic;warming;heat to 60°C)|H2O : 0.99 mg/mL (ultrasonic;warming;adjust pH to 11 with NaOH;heat to 60°C)
Target
– Apoptosis;Autophagy;Endogenous Metabolite;FXR
Isoform
– Human Endogenous Metabolite;Microbial Metabolite
Pathway
– Apoptosis;Autophagy;Metabolic Enzyme/Protease
Product type
– Natural Products
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
