Liproxstatin-1
Add to CompareAdded to Compare

Download Files:

Liproxstatin-1

SKU T2376-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 53 CAD through 1,200 CAD

Products Details

Product Description

– Liproxstatin-1 is a potent and selective inhibitor of ferroptosis (IC50=22 nM). Liproxstatin-1 protects cells from ferroptosis induced by ferroptosis inducers (e.g., Erastin, RSL3).

Web ID

– T2376

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C19H21ClN4

Citations

– 1. Hu G, Cui Z, Chen X, et al.Suppressing Mesenchymal Stromal Cell Ferroptosis Via Targeting a Metabolism‐Epigenetics Axis Corrects their Poor Retention and Insufficient Healing Benefits in the Injured Liver Milieu.Advanced Science.2023: 2206439. 2. Miao Q, Deng W, Lyu W, et al.Erianin inhibits the growth and metastasis through autophagy-dependent ferroptosis in KRASG13D colorectal cancer.Free Radical Biology and Medicine.2023 3. Zhu X, Huang N, Ji Y, et al.Brusatol induces ferroptosis in oesophageal squamous cell carcinoma by repressing GSH synthesis and increasing the labile iron pool via inhibition of the NRF2 pathway.Biomedicine & Pharmacotherapy.2023, 167: 115567. 4. Chen J, Chen Z, Yu D, et al.Neuroprotective Effect of Hydrogen Sulfide Subchronic Treatment Against TBI-Induced Ferroptosis and Cognitive Deficits Mediated Through Wnt Signaling Pathway.Cellular and Molecular Neurobiology.2023: 1-24. 5. Dai B, Su Q, Liu X, et al.2, 2-dimethylthiazolidine hydrochloride protects against experimental contrast-induced acute kidney injury via inhibition of tubular ferroptosis.Biochemical and Biophysical Research Communications.2023 6. Ouyang S, Li H, Lou L, et al. Inhibition of STAT3-ferroptosis negative regulatory axis suppresses tumor growth and alleviates chemoresistance in gastric cancer. Redox Biology. 2022: 102317 7. Zhou Y, Wu H, Wang F, et al. GPX7 Is Targeted by miR-29b and GPX7 Knockdown Enhances Ferroptosis Induced by Erastin in Glioma. Frontiers in oncology. 2021, 11: 802124-802124. 8. Huang H, Chen Y, Yin N, et al. Unsaturated Fatty Acid Liposomes Selectively Regulate Glutathione Peroxidase 4 to Exacerbate Lipid Peroxidation as an Adaptable Liposome Platform for Anti-Tumor Therapy. Molecular Pharmaceutics. 2022 9. Qu W, Cheng Y, Peng W, et al. Targeting iNOS Alleviates Early Brain Injury After Experimental Subarachnoid Hemorrhage via Promoting Ferroptosis of M1 Microglia and Reducing Neuroinflammation. Molecular Neurobiology. 2022: 1-16. 10. Luo Y, Gao X, Zou L, et al. Bavachin Induces Ferroptosis through the STAT3/P53/SLC7A11 Axis in Osteosarcoma Cells. Oxidative Medicine and Cellular Longevity. 2021

References

– Friedmann Angeli JP, et al. Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice. Nat Cell Biol. 2014 Dec;16(12):1180-91.

CAS Number

– 950455-15-9

Molecular Weight

– C19H21ClN4

Compound Purity

– 0.999

SMILES

– Clc1cccc(CNC2=Nc3ccccc3NC22CCNCC2)c1

Pathway

– Apoptosis

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

Related Products

Select options
Mecarbinate
Mecarbinate Price range: 46 CAD through 56 CAD
1 g1 mL * 10 mM (in DMSO)

1000 in stock

Select options
Sodium Nitroprusside
Sodium Nitroprusside Price range: 64 CAD through 139 CAD
1 mL * 10 mM (in DMSO)100 mg50 mg

1000 in stock

Select options
AChE-IN-23
AChE-IN-23 Price range: 66 CAD through 150 CAD
100 mg200 mg50 mg

1000 in stock

Select options
3-Acetylcoumarin
3-Acetylcoumarin 46 CAD
1 mL * 10 mM (in DMSO)500 mg

1000 in stock

Select options
4-Hydroxy-6-methylcoumarin
4-Hydroxy-6-methylcoumarin Price range: 46 CAD through 78 CAD
1 mL * 10 mM (in DMSO)500 mg

1000 in stock

My Cart
Wishlist
Recently Viewed
Categories

Request Data Sheet / Safty Data Sheet

Please enable JavaScript in your browser to complete this form.
=

Price Request

Please enable JavaScript in your browser to complete this form.
=

Compare Products (0 Products)
document.addEventListener('elementor/popup/show', function() { if (typeof turnstile !== 'undefined') { document.querySelectorAll('.cf-turnstile').forEach(function(el) { if (!el.dataset.rendered) { turnstile.render(el); el.dataset.rendered = true; } }); } });