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LFHP-1c
$350 – $2,850
Products Details
Product Description
– LFHP-1c is an PGAM5 inhibitor with neuroprotective activity in brain ischemic stroke. LFHP-1c protects blood-brain barrier integrity from ischemia-induced injury. LFHP-1c binds to endothelial PGAM5 to inhibit the activity of PGAM5 phosphatase and the interaction of PGAM5 with NRF2. LFHP-1c exhibits in vitro and in vivo protection[1].
Web ID
– HY-139598
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C55H64N6O4
References
– [1]Gao C, et al. A novel PGAM5 inhibitor LFHP-1c protects blood-brain barrier integrity in ischemic stroke. Acta Pharm Sin B. 2021 Jul;11(7):1867-1884.
CAS Number
– 2102347-47-5
Molecular Weight
– 873.13
Compound Purity
– 98.07
SMILES
– O=C(C)OC(CCCC)C1=C(C(NCCCCCCCCNC(C2=C(C3=CC=C(CN4C5=CC(C6=NC7=C(N6C)C=CC=C7)=CC(C)=C5N=C4CCC)C=C3)C=CC=C2)=O)=O)C=CC=C1
Clinical Information
– No Development Reported
Research Area
– Cardiovascular Disease
Solubility
– DMSO : 100 mg/mL (ultrasonic)
Target
– Phospholipase
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
