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LDN193189
Price range: 66 CAD through 837 CAD
Products Details
Product Description
– LDN193189 (LDN-193189) (DM 3189) is a selective BMP signaling inhibitor, inhibiting the transcriptional activity of ALK2 and ALK3 (IC50s: 0.8/0.8/5.3/16.7 nM for ALK1/2/3/6).
Web ID
– T1935
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C25H22N6
Citations
– 1. Zhang H, Chen C, Liu Y, et al. NRF-2/HO-1 Pathway-Mediated SHOX2 Activation Is a Key Switch for Heart Rate Acceleration by Yixin-Fumai Granules. Oxidative Medicine and Cellular Longevity. 2022
2. Lu C, Xu C, Li S, et al.Liraglutide and GLP-1 (9-37) alleviated hepatic ischemia-reperfusion injury by inhibiting ferroptosis via GSK3β/Nrf2 pathway and SMAD159/Hepcidin/FTH pathway.Redox Biology.2024: 103468.
3. Qin X, Fu L, Li C, et al.Optimized inner ear organoids for efficient hair cell generation and ototoxicity response modeling.Science China Life Sciences.2025: 1-15.
4. Sex-biased gene expression during neural differentiation of human embryonic stem cells
References
– Yu PB, et al. BMP type I receptor inhibition reduces heterotopic [corrected] ossification. Nat Med. 2008 Dec;14(12):1363-9.
CAS Number
– 1062368-24-4
Molecular Weight
– C25H22N6
Compound Purity
– 0.9967
SMILES
– C1CN(CCN1)c1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccnc2ccccc12
Target
– PI3K|||mTOR
Pathway
– Angiogenesis|||Stem Cells|||Tyrosine Kinase/Adaptors
Product type
– Small Compound
New Class
– Top-SmallMol
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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