LCS3
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LCS3

SKU T60446-1 mg Category Brand:

Price range: 82 CAD through 3,072 CAD

Products Details

Product Description

– LCS3 is a reversible and non-competitive synergistic inhibitor of glutathione disulfide reductase (GSR) and thioredoxin reductase 1 (TXNRD1) with IC50s of 3.3 μM and 3.8 μM, respectively. LCS3 has antitumour activity, induces apoptosis and can be used in the study of lung adenocarcinoma (LUAD).

Web ID

– T60446

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C11H7ClN2O4

References

– Johnson FD, et al. Characterization of a small molecule inhibitor of disulfide reductases that induces oxidative stress and lethality in lung cancer cells. Cell Rep. 2022 ; 38(6):110343.

CAS Number

– 109844-92-0

Molecular Weight

– C11H7ClN2O4

Compound Purity

– 0.9968

SMILES

– [O-][N+](=O)C1=CC=C(O1)C(=O)NC1=CC=C(Cl)C=C1

Pathway

– Apoptosis|||Oxidation-Reduction

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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