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Products Details
Product Description
– LB244 is a homologue of BB-Cl-amidine, which is an orally effective STING inhibitor (EC50=0.8 μM) and can be used to inhibit STING-dependent inflammatory diseases. The pharmacokinetic properties of LB244 indicate limited oral activity in mice[1].
Web ID
– HY-156117
Shipping
– Room temperature
Molecular Formula
– C30H27N5O5
References
– [1]Barasa L, et al. Development of LB244, an Irreversible STING Antagonist. J Am Chem Soc. 2023 Sep 20;145(37):20273-20288..
Molecular Weight
– 537.57
SMILES
– O=C(N[C@@H](CCCCNC(C1=CC=C(O1)[N+]([O-])=O)=O)C2=NC3=CC=CC=C3N2)C(C=C4)=CC=C4C5=CC=CC=C5
Clinical Information
– No Development Reported
Research Area
– cancer
Solubility
– 10 mM in DMSO
Target
– STING
Pathway
– Immunology/Inflammation
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
