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L82
$80 – $600
Products Details
Product Description
– L82 is a selective and uncompetitive DNA ligase 1 (DNA Lig1) inhibitor (hLig1 IC50=12 μM). L82 shows anti-proliferative activity to breast cancer cells[1][2].
Web ID
– HY-15587
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Molecular Formula
– C11H8ClN5O4
References
– [1]Howes TRL, et al. Structure-activity relationships among DNA ligase inhibitors: Characterization of a selective uncompetitive DNA ligase I inhibitor. DNA Repair (Amst). 2017 Dec;60:29-39.|[2]Chen X, et al. Rational design of human DNA ligase inhibitors that target cellular DNA replication and repair. Cancer Res. 2008 May 1;68(9):3169-77.
CAS Number
– 329227-30-7
Molecular Weight
– 309.67
Compound Purity
– 98.12
SMILES
– O=C1NN=CC(N/N=C/C2=CC=C(C([N+]([O-])=O)=C2)O)=C1Cl
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 33.33 mg/mL (ultrasonic)
Target
– DNA/RNA Synthesis
Pathway
– Cell Cycle/DNA Damage
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
