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L-Thyroxine (sodium)
$60 – $78
Products Details
Product Description
– L-Thyroxine sodium (Levothyroxine sodium) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4)[1].
Web ID
– HY-18341B
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture and light)
Shipping
– Room Temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C15H10I4NNaO4
Citations
– J Drug Deliv Sci Technol. 2023 Sep 28, 105008.|Cell Rep Med. 2023 May 24;101061.|Mol Brain. 2021 Jan 27;14(1):25.|Sci Rep. 2022 Jul 4;12(1):11259.|Stem Cell Rev Rep. 2021 Jun;17(3):999-1013.
References
– [1]Arici M, et al. Association between genetic polymorphism and levothyroxine bioavailability in hypothyroid patients. Endocr J. 2018 Mar 28;65(3):317-323.|[2]Corriveau S, et al. Levothyroxine treatment generates an abnormal uterine contractility patterns in an in vitro animalmodel. J Clin Transl Endocrinol. 2015 Sep 9;2(4):144-149.
CAS Number
– 55-03-8
Molecular Weight
– 798.85
Compound Purity
– 99.50
SMILES
– N[C@@H](CC1=CC(I)=C(OC2=CC(I)=C(O)C(I)=C2)C(I)=C1)C(O[Na])=O
Clinical Information
– Launched
Research Area
– Endocrinology; Cancer
Solubility
– 0.5 M NaOH : 25 mg/mL (ultrasonic;warming;adjust pH to 11 with NaOH;heat to 60°C)|DMSO : 62.5 mg/mL (ultrasonic)|H2O : 14 mg/mL (ultrasonic;adjust pH to 12 with NaOH)
Target
– Endogenous Metabolite;Thyroid Hormone Receptor
Isoform
– Human Endogenous Metabolite
Pathway
– Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
