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L-Ascorbic acid
$30 – $50
Products Details
Product Description
– L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid is also a collagen deposition enhancer and an elastogenesis inhibitor[1][2][3]. L-Ascorbic acid exhibits anti-cancer effects through the generation of reactive oxygen species (ROS) and selective damage to cancer cells[4].
Web ID
– HY-B0166
Storage Temperature
– 4°C (Powder, protect from light)
Shipping
– Room Temperature
Applications
– Metabolism-sugar/lipid metabolism
Molecular Formula
– C6H8O6
Citations
– Antioxid Redox Signal. 2020 Dec 10;33(17):1191-1208.|Biomed Pharmacother. September 2022, 113558.|Bioorg Chem. 2021, 105177.|Biosci Rep. 2019 May 21;39(5):BSR20182137.|Cell Biol Toxicol. 2021 Jul 20.|Cell Cycle. 2022 Nov 12;1-18.|Cytotechnology. 02 October 2021.|Drug Chem Toxicol. 2023 Feb 23;1-9.|Eur J Med Chem. 2022 Jan 28;231:114151.|Fitoterapia. 2021 Jun 30;104984.|Food Funct. 2022 May 10;13(9):5089-5101.|Free Radic Biol Med. 2020 Feb 1;147:220-230.|Int J Biol Macromol. 2023 Nov 17:127779.|J Biol Chem. 2023 Nov 15:105462.|J Cell Mol Med. 2020 Apr;24(7):4212-4222.|J Nat Prod. 2022 Jul 7.|J Neurosci Res. 2019 Dec;97(12):1689-1705. |J Pharmacol Toxicol Methods. Nov-Dec 2020;106:106913.|J Sex Med. 2018 Feb;15(2):136-147. |Mol Med Rep. 2019 Dec; 20(6): 4933–4942.|Nat Immunol. 2022 Dec 21.|Nigerian Journal of Scientific Research. 18 (3): 2019.|Oxid Med Cell Longev. 2022 Jan 27;2022:7502632.|Redox Biol. 2022 Aug;54:102392.|Research Square Print. 2022 Aug.|Sci China Life Sci. 2018 Oct;61(10):1151-1167.|Environ Toxicol. 2021 Apr;36(4):520-529.|FASEB J. 2020 Sep;34(9):11474-11487.|J Afr Ass Physiol Sci. 7(1): 30-37, July 2019.|Mil Med Res. 2020 Nov 1;7(1):52.
References
– [1]Sebastian J Padayatty, et al. Vitamin C as an antioxidant: evaluation of its role in disease prevention. J Am Coll Nutr. 2003 Feb;22(1):18-35.|[2]Michael T Nelson, et al. Molecular mechanisms of subtype-specific inhibition of neuronal T-type calcium channels by ascorbate. J Neurosci. 2007 Nov 14;27(46):12577-83.|[3]Aleksander Hinek, et al. Sodium L-ascorbate enhances elastic fibers deposition by fibroblasts from normal and pathologic human skin. J Dermatol Sci. 2014 Sep;75(3):173-82.|[4]Sungrae Cho, et al. Hormetic dose response to L-ascorbic acid as an anti-cancer drug in colorectal cancer cell lines according to SVCT-2 expression. Sci Rep. 2018 Jul 27;8(1):11372.|[5]Satyanarayana Sreemantula, et al. Influence of antioxidant (L- ascorbic acid) on tolbutamide induced hypoglycaemia/antihyperglycaemia in normal and diabetic rats. BMC Endocr Disord. 2005 Mar 3;5(1):2.
CAS Number
– 50-81-7
Molecular Weight
– 176.12
Compound Purity
– 99.92
SMILES
– OC([C@@]1([H])[C@H](CO)O)=C(O)C(O1)=O
Clinical Information
– Launched
Research Area
– Cancer; Metabolic Disease; Neurological Disease
Solubility
– DMSO : 100 mg/mL (ultrasonic)|H2O : ≥ 100 mg/mL
Target
– Apoptosis;Calcium Channel;Endogenous Metabolite;Reactive Oxygen Species
Isoform
– Human Endogenous Metabolite;Microbial Metabolite;T-type calcium channel
Pathway
– Apoptosis;Immunology/Inflammation;Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease;Neuronal Signaling;NF-κB
Product type
– Natural Products
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
