KU 59403

$350$550

Products Details

Product Description

– KU 59403 is a potent ATM inhibitor, with IC50 values of 3 nM, 9.1 μM and 10 μM for ATM, DNA-PK and PI3K, respectively[1].

Web ID

– HY-18650

Storage Temperature

– -20°C (Powder, sealed storage, away from moisture)

Shipping

– Blue Ice

Applications

– Cancer-Kinase/protease

Molecular Formula

– C29H32N4O4S2

References

– [1]Batey MA, et al. Preclinical evaluation of a novel ATM inhibitor, KU59403, in vitro and in vivo in p53 functional and dysfunctional models of human cancer. Mol Cancer Ther. 2013 Jun;12(6):959-67.

CAS Number

– 845932-30-1

Molecular Weight

– 564.72

Compound Purity

– 99.23

SMILES

– O=C(NC(C=C1S2)=CC=C1SC3=C2C=CC=C3C4=CC(C=C(N5CCOCC5)O4)=O)CCN6CCN(C)CC6

Clinical Information

– No Development Reported

Research Area

– Cancer

Solubility

– DMSO : 10 mg/mL (ultrasonic;warming;heat to 60°C)

Target

– ATM/ATR

Pathway

– Cell Cycle/DNA Damage;PI3K/Akt/mTOR

Product type

– Reference compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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