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KPT-251
$316
Only 1000 item(s) left in stock.
Products Details
Product Description
– KPT-251 is an orally active chromosome region maintenance 1 protein (CRM1) inhibitor. KPT-251 induces cancer cell apoptosis and shows antileukemic activity[1][2].
Web ID
– HY-117996
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C14H7F6N5O
References
– [1]Etchin J, et al. Antileukemic activity of nuclear export inhibitors that spare normal hematopoietic cells. Leukemia. 2013 Jan;27(1):66-74.|[2]Salas Fragomeni RA, et al. CRM1 and BRAF inhibition synergize and induce tumor regression in BRAF-mutant melanoma. Mol Cancer Ther. 2013 Jul;12(7):1171-9.
CAS Number
– 1388841-50-6
Molecular Weight
– 375.23
SMILES
– FC(C1=CC(C(F)(F)F)=CC(C2=NN(/C=CC3=NN=CO3)C=N2)=C1)(F)F
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;CRM1
Pathway
– Apoptosis;Membrane Transporter/Ion Channel
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
