KN-93
Add to CompareAdded to Compare

Download Files:

KN-93

SKU T2697-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 83 CAD through 931 CAD

Products Details

Product Description

– KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII), competitively blocking CaM binding to the kinase.

Web ID

– T2697

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C26H29ClN2O4S

Citations

– 1. Xuexian Fang, Hao Wang, Dan Han, Enjun Xie, Xiang Yang, Jiayu Wei, Shanshan Gu et al. Ferroptosis as a target for protection against cardiomyopathy. Proceedings of the National Academy of Sciences of the United States of America. 2019 Feb 12;116(7):2672-2680. 2. Zheng Q, Zou Y, Teng P, et al. Mechanosensitive Channel PIEZO1 Senses Shear Force to Induce KLF2/4 Expression via CaMKII/MEKK3/ERK5 Axis in Endothelial Cells. Cells. 2022, 11(14): 2191 3. Pan X, Li R, Guo H, et al. Dihydropyridine Calcium Channel Blockers Suppress the Transcription of PD-L1 by Inhibiting the Activation of STAT1. Frontiers in Pharmacology. 2021 Jan 13;11:539261. doi: 10.3389/fphar.2020.539261. eCollection 2020. 4. Jiang Q, Li Y, Mao R, et al.AaCaMKs Positively Regulate Development, Infection Structure Differentiation and Pathogenicity in Alternaria alternata, Causal Agent of Pear Black Spot.International Journal of Molecular Sciences.2023, 24(2): 1381. 5. Yin Z, Zhang J, Zhao M, et al.Maresin‐1 ameliorates hypertensive vascular remodeling through its receptor LGR6.MedComm.2024, 5(3): e491. 6. Fan Y, Huang S, Li S, et al.The adipose-neural axis is involved in epicardial adipose tissue-related cardiac arrhythmias.Cell Reports Medicine.2024

References

– Tombes RM, et al. G1 cell cycle arrest and apoptosis are induced in NIH 3T3 cells by KN-93, an inhibitor of CaMK (the multifunctional Ca2+/CaM kinase). Cell Growth Differ. 1995 Sep;6(9):1063-70.

CAS Number

– 139298-40-1

Molecular Weight

– C26H29ClN2O4S

Compound Purity

– 0.9986

SMILES

– N(S(=O)(=O)C1=CC=C(OC)C=C1)(CCO)C2=C(CN(CC=CC3=CC=C(Cl)C=C3)C)C=CC=C2

Pathway

– Autophagy|||Neuroscience

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

Related Products

Read more
(R)-(+)-Atenolol
(R)-(+)-Atenolol
Select options
2,2'-Bipyridine
2,2′-Bipyridine Price range: 46 CAD through 171 CAD
1 g100 mg500 mg

1000 in stock

Select options
7-Chloro-4-(piperazin-1-yl)quinoline
7-Chloro-4-(piperazin-1-yl)quinoline Price range: 56 CAD through 77 CAD
100 mg200 mg

1000 in stock

Select options
Jedi2
Jedi2 Price range: 53 CAD through 1,117 CAD
1 mg1 mL * 10 mM (in DMSO)5 mg

1000 in stock

Select options
7-Methoxy-1-tetralone
7-Methoxy-1-tetralone Price range: 46 CAD through 56 CAD
1 g1 mL * 10 mM (in DMSO)

1000 in stock

My Cart
Wishlist
Recently Viewed
Categories

Request Data Sheet / Safty Data Sheet

Please enable JavaScript in your browser to complete this form.
=

Price Request

Please enable JavaScript in your browser to complete this form.
=

Compare Products (0 Products)
document.addEventListener('elementor/popup/show', function() { if (typeof turnstile !== 'undefined') { document.querySelectorAll('.cf-turnstile').forEach(function(el) { if (!el.dataset.rendered) { turnstile.render(el); el.dataset.rendered = true; } }); } });