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KN-93
$73 – $620
Products Details
Product Description
– KN-93 is a cell-permeable, reversible and competitive inhibitor calmodulin-dependent kinase type II (CaMKII) with a Ki of 370 nM.
Web ID
– HY-15465
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C26H29ClN2O4S
Citations
– Acta Pharmacol Sin. 2020 Feb;41(2):218-228. |Ann Transl Med. 2020 Mar;8(5):219.|Arch Toxicol. 2019 Jun;93(6):1697-1712. |Biochem Biophys Res Commun. 2022 Apr 20;615:136-142.|Biochem Biophys Res Commun. 2022 Jun 25;610:170-175.|Biochem Pharmacol. 2021 Aug 9;114722.|Brain Res Bull. 2020 May;158:66-76.|Brain Res. 2023 Nov 2:148665.|Cell Calcium. 2021 Oct 5;100:102483.|Cell Cycle. 2019 Nov;18(21):2986-2997.|Cell Death Dis. 2021 May 18;12(6):504.|Cell Mol Life Sci. 2022 Dec 1;79(12):613.|Cell Signal. 2022 Dec 21;103:110569.|Cell Syst. 2018 Apr 25;6(4):424-443.e7.|Cell. 2022 Jun 23;185(13):2354-2369.e17.|Diabetes. 2018 Sep;67(9):1748-1760.|Diabetol Metab Syndr. 2023 Oct 28;15(1):217.|EMBO Mol Med. 2022 Dec 13;e16373.|Evid-Based Compl Alt. Dec 12.|Exp Cell Res. 2018 Mar 15;364(2):198-207. |FASEB J. 2019 Dec;33(12):13644-13659.|FEBS Lett. 2022 Jun 18.|Front Genet. 2022 Aug 4;13:959360.|Front Pharmacol. 2018 Apr 12;9:362. |Front Pharmacol. 2022, 13: 5319.|Harvard Medical School LINCS LIBRARY|J Agric Food Chem. 2019 Dec 26;67(51):14074-14085.|J Cell Biochem. 2019 Aug;120(8):13095-13106.|J Cell Mol Med. 2020 Aug;24(16):9287-9299.|J Endocrinol. 2018 Mar;236(3):151-165. |J Ethnopharmacol. 2023 Aug 9;117016.|J Mol Cell Cardiol. 2021 Nov 10;S0022-2828(21)00210-8.|J Mol Histol. 2021 Apr 26.|J Neurosci. 2022 Jun 27;JN-RM-1989-21.|Life Sci. 2020 Apr 1;246:117419.|Neurosci Lett. 2021 Feb 1;135699.|Neuroscience. 4 March 2022.|Oncol Rep. 2019 Jun;41(6):3413-3423. |Oxid Med Cell Longev. 2019 Dec 7;2019:2193019.|Oxid Med Cell Longev. 2021 Mar 30.|Redox Biol. October 2021, 102115.|Research Square Preprint. 2021 Oct.|Sci Total Environ. 2020 Feb 10;703:134702.|Toxicology. 2023 Apr 17, 153514.|Transl Stroke Res. 2023 Feb 13.|World J Diabetes. 2022 Apr 15;13(4):338-357.|Commun Biol. 2022 Jul 28;5(1):750.|Front Med. 2023 Feb 4.|Nat Commun. 2022 Jul 22;13(1):4255.|Nat Metab. 2020 Sep;2(9):918-933.
References
– [1]Anderson ME, et al. KN-93, an inhibitor of multifunctional Ca++/calmodulin-dependent protein kinase, decreases early afterdepolarizations in rabbit heart. J Pharmacol Exp Ther. 1998 Dec;287(3):996-1006.|[2]Tombes RM, et al. G1 cell cycle arrest and apoptosis are induced in NIH 3T3 cells by KN-93, an inhibitor of CaMK (the multifunctional Ca2+/CaM kinase). Cell Growth Differ. 1995 Sep;6(9):1063-70.|[3]Li J, et al. Curcumin Attenuates Retinal Vascular Leakage by Inhibiting Calcium/Calmodulin-Dependent Protein Kinase II Activity in Streptozotocin-Induced Diabetes. Cell Physiol Biochem. 2016;39(3):1196-208.|[4]Mamiya N, et al. Inhibition of acid secretion in gastric parietal cells by the Ca2+/calmodulin-dependent protein kinase II inhibitorKN-93. Biochem Biophys Res Commun. 1993 Sep 15;195(2):608-15.
CAS Number
– 139298-40-1
Molecular Weight
– 501.04
Compound Purity
– 99.19
SMILES
– O=S(C1=CC=C(OC)C=C1)(N(C2=CC=CC=C2CN(C/C=C/C3=CC=C(Cl)C=C3)C)CCO)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 50 mg/mL (ultrasonic)|H2O : 1 mg/mL (ultrasonic;warming;heat to 60°C)
Target
– Autophagy;CaMK
Isoform
– CaMK II
Pathway
– Autophagy;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
