KG5
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KG5

SKU T41003-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 46 CAD through 1,059 CAD

Products Details

Product Description

– KG5 is a dual allosteric inhibitor of PDGFRβ and B-Raf with a Kd of 520 nM and 300 nM for PDGFRβ and PDGFRα. KG5 inhibits FLT3, KIT, and c-Raf with anticancer and antiangiogenic activities.

Web ID

– T41003

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C20H16F3N7OS

References

– Eric A Murphy, et al. Disruption of angiogenesis and tumor growth with an orally active drug that stabilizes the inactive state of PDGFRbeta/B-RAF. Proc Natl Acad Sci U S A. 2010 Mar 2;107(9):4299-304.

CAS Number

– 877874-85-6

Molecular Weight

– C20H16F3N7OS

Compound Purity

– 0.982

SMILES

– CSc1nc(N)cc(Oc2ccc(cc2)-c2nnc(Nc3cccc(c3)C(F)(F)F)[nH]2)n1

Pathway

– Tyrosine Kinase/Adaptors|||MAPK|||Angiogenesis

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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