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K145 (hydrochloride)
$79 – $898
Products Details
Product Description
– K145 hydrochloride is a selective, substrate-competitive and orally active SphK2 inhibitor with an IC50 of 4.3 µM and a Ki of 6.4 µM. K145 hydrochloride is inactive against SphK1 and other protein kinases. K145 hydrochloride induces cell apoptosis and has potently antitumor activity[1].
Web ID
– HY-15779A
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C18H25ClN2O3S
Citations
– Biochem Biophys Res Commun. 2021 Sep 28;580:1-6.|Am J Cancer Res. 2019 Mar 1;9(3):546-561.|Biochem Biophys Res Commun. 2017 Nov 4;493(1):286-290. |Channels. 2020 Dec;14(1):216-230.|Exp Mol Pathol. 2016 Feb;100(1):51-8. |Sci China Life Sci. 2021 May 27;1-21.
References
– [1]Liu K, et al. Biological characterization of 3-(2-amino-ethyl)-5-[3-(4-butoxyl-phenyl)-propylidene]-thiazolidine-2,4-dione (K145) as a selective sphingosine kinase-2 inhibitor and anticancer agent. PLoS One. 2013;8(2):e56471.
CAS Number
– 1449240-68-9
Molecular Weight
– 384.92
Compound Purity
– 99.63
SMILES
– O=C(N(CCN)C/1=O)SC1=C/CCC2=CC=C(OCCCC)C=C2.[H]Cl
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 50 mg/mL (ultrasonic)|H2O : 126.7 mg/mL (ultrasonic;warming)
Target
– Apoptosis;SphK
Isoform
– SphK2
Pathway
– Apoptosis;Immunology/Inflammation
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
