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Products Details
Product Description
– JTC-017, a specific corticotropin-releasing hormone receptor 1 antagonist, attenuates hippocampal noradrenaline release, visceral perception, adrenocorticotropic hormone release, and anxiety after acute colorectal distention in rats. JTC-017 blocks stress-induced changes in colonic motility after chronic colorectal distention in rats[1].
Web ID
– HY-118821
Shipping
– Room temperature
Molecular Formula
– C20H25Cl2N3O5S
References
– [1]Saito K, et al. Corticotropin-releasing hormone receptor 1 antagonist blocks brain-gut activation induced by colonic distention in rats. Gastroenterology. 2005;129(5):1533-1543.
CAS Number
– 357330-77-9
Molecular Weight
– 490.40
SMILES
– O=C(C1=CC(Cl)=C(C(Cl)=C1)O)NC2=CC(S(=O)(N(CC)CC)=O)=CC(N(C)C)=C2OC
Clinical Information
– No Development Reported
Research Area
– Metabolic Disease
Solubility
– 10 mM in DMSO
Target
– CRFR
Pathway
– GPCR/G Protein
Product type
– Reference compound
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