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JR-AB2-011
Price range: 139 CAD through 2,128 CAD
Products Details
Product Description
– JR-AB2-011 is a selective mTORC2 inhibitor with an IC50 value of 0.36 μM. It inhibits mTORC2 activity by blocking Rictor-mTOR association (Ki: 0.19 μM) and exhibits cytotoxicity in glioblastoma [1].
Web ID
– T11728
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C17H14Cl2FN3OS
Citations
– 1. Xu W, Qadir M M F, Nasteska D, et al.Architecture of androgen receptor pathways amplifying glucagon-like peptide-1 insulinotropic action in male pancreatic β cells.Cell Reports.2023, 42(5).
2. Zhou S, Lin W, Jin X, et al.CD97 maintains tumorigenicity of glioblastoma stem cells via mTORC2 signaling and is targeted by CAR Th9 cells.Cell Reports Medicine.2024
References
– Benavides-Serrato A, et al. Correction: Specific blockade of Rictor-mTOR association inhibits mTORC2 activity and is cytotoxicin glioblastoma. PLoS One. 2019 Feb 6;14(2):e0212160.
CAS Number
– 2411853-34-2
Molecular Weight
– C17H14Cl2FN3OS
Compound Purity
– 0.9887
SMILES
– CC1CN(C(=O)Nc2ccc(Cl)c(Cl)c2)C(S1)=Nc1ccc(F)cc1
Target
– Others
Pathway
– PI3K/Akt/mTOR signaling
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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