Download Files:
JO146
$172 – $3,420
Products Details
Product Description
– JO146 is a Chlamydia trachomatis high temperature requirement A (CtHtrA) protease inhibitor with IC50s of 21.86 and 1.15 μM for CtHtrA and human neutrophil elastase (HNE), respectively. JO146 can be used to inhibits bacterial infections[1].
Web ID
– HY-144820
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C31H44N3O7P
References
– [1]Jimin Hwang, et al. Design, synthesis and biological evaluation of P2-modified proline analogues targeting the HtrA serine protease in <i>Chlamydia</i>. Eur J Med Chem. 2022 Feb 15;230:114064.
CAS Number
– 130727-21-8
Molecular Weight
– 601.67
Compound Purity
– 98.49
SMILES
– O=C(OC(C)(C)C)N[C@@H](C(C)C)C(N1[C@H](C(NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)C(C)C)=O)CCC1)=O
Clinical Information
– No Development Reported
Research Area
– Infection
Solubility
– 10 mM in DMSO
Target
– Ser/Thr Protease
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
