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Products Details
Product Description
– JNK3 inhibitor-8 is a potent, delective, orally active and cross the blood-brain barrier JNK3 inhibitor with IC50 values of 21, 2203, >10000 nM for JNK3, JNK2, JNK1, respectively. JNK3 inhibitor-8 shows significant neuroprotective effects. JNK3 inhibitor-8 has the potential for the research of Alzheimer’s disease (AD)[1].
Web ID
– HY-149280
Shipping
– Room temperature
Molecular Formula
– C32H30FN7O3
References
– [1]Jun J, et al. Carbamate JNK3 Inhibitors Show Promise as Effective Treatments for Alzheimer’s Disease: In Vivo Studies on Mouse Models. J Med Chem. 2023 Apr 24.
Molecular Weight
– 579.62
SMILES
– O=C(N1C[C@@H](NC2=NC=CC(N3C4=C(N=C3C5=CC6=C(C=C5)C=CC=C6)C(F)=CC(OC(NC)=O)=C4)=N2)CCC1)C7CC7
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– JNK
Isoform
– JNK1;JNK2;JNK3
Pathway
– MAPK/ERK Pathway
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
