Download Files:
JNK-IN-8
$50 – $935
Products Details
Product Description
– JNK-IN-8 (JNK Inhibitor XVI) is a potent JNK inhibitor with IC50s of 4.7 nM, 18.7 nM, and 1 nM for JNK1, JNK2, and JNK3, respectively[1].
Web ID
– HY-13319
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C29H29N7O2
References
– [1]Zhang T, et al.
Discovery of potent and selective covalent inhibitors of JNK.
Chem Biol. 2012 Jan 27;19(1):140-54.|[2]Liu Q, et al. Developing irreversible inhibitors of the protein kinase cysteinome. Chem Biol. 2013 Feb 21;20(2):146-59.
CAS Number
– 1410880-22-6
Molecular Weight
– 507.59
Compound Purity
– 99.67
SMILES
– CC1=CC(NC(C2=CC=CC(NC(/C=C/CN(C)C)=O)=C2)=O)=CC=C1NC3=NC=CC(C4=CN=CC=C4)=N3
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : ≥ 35 mg/mL
Target
– JNK
Isoform
– JNK1;JNK2;JNK3
Pathway
– MAPK/ERK Pathway
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
