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Products Details
Product Description
– JNJ525 is an inhibitor of TNFα. JNJ525 inhibits protein function via an aggregation-based mechanism. JNJ525 prevents the formation of TNFα complexes with TNFR1 and TNFR2, the apparent IC50 values for the inhibition of complex formation are 1.2 ± 0.2 μM and 1.1 ± 0.1 μM respectively in the TR-FRET assay.
Web ID
– T27687
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C31H30N8
References
– Structural Basis of Small-Molecule Aggregate Induced Inhibition of a Protein–Protein Interaction Jonathan M. BlevittMichael D. HackKrystal L. HermanPaul F. JacksonPaul J. KrawczukAlec D. LebsackAnnie X. LiuTaraneh MirzadeganMarina I. NelenAaron N. PatrickStefan SteinbacherMarcos E. Millaand Kevin J. Lumb Publication Date (Web): March 16, 2017 (Brief Article) doi: 10.1021/acs.jmedchem.6b01836
Molecular Weight
– C31H30N8
SMILES
– NC1=NC=CC(N(CC2=CC=CC=C2)C(C=CC=C3)=C3C4=CC=CC(C5=CN=C(N6CCNCC6)N=C5)=C4)=N1
Pathway
– Others
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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