Products Details

Product Description

– JNJ-10311795 (RWJ-355871), a potent dual inhibitor of neutrophil cathepsin G (Ki = 38 nM) and mast cell chymase (Ki = 2.3 nM), exhibits noteworthy antiinflammatory activity[1].

Web ID

– HY-122161

Shipping

– Room temperature

Molecular Formula

– C40H35N2O6P

References

– [1]Lawrence de Garavilla, et al. A novel, potent dual inhibitor of the leukocyte proteases cathepsin G and chymase: molecular mechanisms and anti-inflammatory activity in vivo. J Biol Chem. 2005 May 6;280(18):18001-7.

CAS Number

– 518062-14-1

Molecular Weight

– 670.69

SMILES

– OP(O)(C(C1=C2C=CC=CC2=CC=C1)C(C3=C(C(N(C)C4CCN(C(C5=CC=C6C=CC=CC6=C5)=O)CC4)=O)C=C7C=CC=CC7=C3)=O)=O

Clinical Information

– No Development Reported

Research Area

– Inflammation/Immunology

Solubility

– 10 mM in DMSO

Target

– Cathepsin

Pathway

– Metabolic Enzyme/Protease

Product type

– Reference compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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