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JNJ-10229570
$138 – $1,700
Products Details
Product Description
– JNJ-10229570 is an antagonist of melanocortin receptor 1 (MC1R) and melanocortin receptor 5 (MC5R), which inhibits sebaceous gland differentiation and the production of sebum-specific lipids. JNJ-10229570 inhibits the binding of 125I-NDP-α-MSH to cells expressing human MC1R and MC5R, with IC50 values of 270 nM and 200 nM, respectively.
Web ID
– HY-107139
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Molecular Formula
– C22H19N3O2S
References
– [1]Eisinger M, et al. A melanocortin receptor 1 and 5 antagonist inhibits sebaceous gland differentiation and the production of sebum-specific lipids. J Dermatol Sci. 2011 Jul;63(1):23-32.
CAS Number
– 524923-88-4
Molecular Weight
– 389.47
Compound Purity
– 98.0
SMILES
– COC1=C(C=CC=C1)C(N(C2=C(C=CC=C2)OC)S/3)=NC3=NC4=CC=CC=C4
Clinical Information
– No Development Reported
Research Area
– Endocrinology
Solubility
– DMSO : 62.5 mg/mL (ultrasonic)
Target
– Melanocortin Receptor
Isoform
– MC1R;MC5R
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
