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JHU-083
$320 – $1,100
Products Details
Product Description
– JHU-083, a proagent of 6-diazo-5-oxo-L-norleucine (DON; HY-108357), is an orally active and selective glutaminase antagonist. JHU-083 blocks glutaminase activity in brain CD11b+ cells and experimental cerebral malaria (ECM) resulting in a net decrease of glutamate levels in the animals[1][2].
Web ID
– HY-122218
Storage Temperature
– -80°C, sealed storage, away from moisture and light
Shipping
– Dry Ice
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C14H24N4O4
References
– [1]Zhu X, et al. JHU-083 selectively blocks glutaminase activity in brain CD11b+ cells and prevents depression-associated behaviors induced by chronic social defeat stress. Neuropsychopharmacology. 2019 Mar;44(4):683-694.|[2]Riggle BA, et al. MRI demonstrates glutamine antagonist-mediated reversal of cerebral malaria pathology in mice. Proc Natl Acad Sci U S A. 2018 Dec 18;115(51):E12024-E12033.
CAS Number
– 1998725-11-3
Molecular Weight
– 312.36
Compound Purity
– 98.0
SMILES
– O=C(OCC)[C@H](CCC(C=[N+]=[N-])=O)NC([C@H](CC(C)C)N)=O
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– DMSO : 100 mg/mL (ultrasonic)|Ethanol : 133.33 mg/mL (ultrasonic)|H2O : 50 mg/mL (ultrasonic)
Target
– Glutaminase
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
