JH-VIII-157-02
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JH-VIII-157-02

SKU T15612-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 189 CAD through 1,744 CAD

Products Details

Product Description

– JH-VIII-157-02 is an inhibitor of ALK and inhibits echinoderm microtubule-associated protein-like 4-ALK (EML4-ALK) with IC50s of 2 nM for EML4-ALK G1202R, EML4-ALKwt, EML4-ALK C1156Y, EML4-ALK F1174L, and EML4-ALK F1174L.

Web ID

– T15612

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C28H27N5O2

References

– Hatcher JM, et al. Discovery of Inhibitors That Overcome the G1202R Anaplastic Lymphoma Kinase Resistance Mutation. J Med Chem. 2015 Dec 10;58(23):9296-9308.

CAS Number

– 1639422-97-1

Molecular Weight

– C28H27N5O2

Compound Purity

– 0.9802

SMILES

– CCc1cc2C(=O)c3c([nH]c4cc(ccc34)C#N)C(C)(C)c2cc1-c1cnn(CC(=O)N(C)C)c1

Target

– Others

Pathway

– Angiogenesis|||Tyrosine Kinase/Adaptors|||Cytoskeletal Signaling

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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