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JF-NP-26
$790
Only 1000 item(s) left in stock.
Products Details
Product Description
– JF-NP-26, an inactive photocaged derivative of raseglurant, is the first caged mGlu5 receptor negative allosteric modulator. Uncaging of JF-NP-26 is elicited with light pulses in the visible spectrum (405 nm). JF-NP-26 induces light-dependent analgesia in models of inflammatory and neuropathic pain in freely behaving animals[1].
Web ID
– HY-131019
Shipping
– Room temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C30H28FN3O4
References
– [1]Font J, et al. Optical control of pain in vivo with a photoactive mGlu5 receptor negative allosteric modulator [published correction appears in Elife. 2018 Jan 08;7:]. Elife. 2017;6:e23545. Published 2017 Apr 11.
CAS Number
– 2341841-03-8
Molecular Weight
– 513.56
SMILES
– O=C(OCC(C1=CC=C(N(CC)CC)C=C1O2)=CC2=O)NC3=C(C)C=C(C)N=C3C#CC4=CC=CC(F)=C4
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– mGluR
Isoform
– mGluR5
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
