Download Files:
Products Details
Product Description
– JAK-IN-27 (Compound 1) is a JAK inhibitor. JAK-IN-27 inhibits TYK2, JAK1, JAK2 with IC50s of 3.0, 7.7, 8.5 nM respectively. JAK-IN-27 inhibits IFN-α2b induced p-STAT3 in Jurkat cells (IC50: 23.7 nM)[1].
Web ID
– HY-153702
Shipping
– Room temperature
Molecular Formula
– C20H21F2N7O
References
– [1]Zhang Panpan. Pyrazolo [1,5-a ] pyrazine derivative and preparation method and application thereof. Patent. CN113150012.|[2]Zhang P, et al. Preparation of pyrazolo[1,5-a]pyrazine derivatives and its use as JAK family kinase inhibitors. China, CN113150012 A. 2021-07-23.
CAS Number
– 2673176-36-6
Molecular Weight
– 413.42
SMILES
– O=C([C@H](C1)C1(F)F)N2[C@H]3CN(C[C@@H]2CC3)C4=NC(C(C=N5)=CN5C)=CN6C4=CC=N6
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– JAK
Pathway
– Epigenetics;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
