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Products Details
Product Description
– Izuforant (JW1601) (Compound 24) is an orally active histamine H4 receptor (H4R) antagonist with an IC50 of 36 nM against human H4R. Izuforant also shows binding affinity of human serotonin 3 receptor (h5-HT3R) with an IC50 of 9.1 μM. Izuforant exhibits strong anti-pruritic and anti-inflammatory efficacies[1][2].
Web ID
– HY-147276
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C12H12BrN7
References
– [1]Pil Su Ho, et al. Novel heterocyclic derivatives and their uses. WO2013048214A2.|[2]Jin M, et al. From Bench to Clinic: the Potential of Therapeutic Targeting of the IL-22 Signaling Pathway in Atopic Dermatitis. Immune Netw. 2018 Dec 19;18(6):e42.
CAS Number
– 1429374-83-3
Molecular Weight
– 334.17
SMILES
– CNC1CN(C2=NC3=NC=C(Br)C=C3N4C2=NN=C4)C1
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Histamine Receptor
Isoform
– H4 Receptor
Pathway
– GPCR/G Protein;Immunology/Inflammation;Neuronal Signaling
Product type
– Reference compound
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