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Ivacaftor (hydrate)
SKU
HY-13017B-Get quote
Category Reference compound
Tags Autophagy;CFTR, Autophagy;Membrane Transporter/Ion Channel, Endocrinology
Products Details
Product Description
– Ivacaftor hydrate (VX-770 hydrate) is an orally bioavailable CFTR potentiator, used for cystic fibrosis treatment.
Web ID
– HY-13017B
Shipping
– Room temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C24H30N2O4
References
– [1]Van Goor F, et al. Rescue of CF airway epithelial cell function in vitro by a CFTR potentiator, VX-770. Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18825-30.|[2]Mutyam V, et al. Therapeutic benefit observed with the CFTR potentiator, ivacaftor, in a CF patient homozygous for the W1282X CFTR nonsense mutation. J Cyst Fibros. 2017 Jan;16(1):24-29|[3]Delaunay JL, et al. Functional defect of variants in the adenosine triphosphate-binding sites of ABCB4 and their rescue by the cystic fibrosis transmembrane conductance regulator potentiator, ivacaftor (VX-770). Hepatology. 2017 Feb;65(2):560-570|[4]Hadida S, et al. Discovery of N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide (VX-770, ivacaftor), a potent and orally bioavailable CFTR potentiator. J Med Chem. 2014 Dec 11;57(23):9776-9
CAS Number
– 1134822-07-3
Molecular Weight
– 410.51
SMILES
– CC(C)(C1=C(C=C(C(C(C)(C)C)=C1)O)NC(C2=CNC3=C(C2=O)C=CC=C3)=O)C.O
Clinical Information
– Launched
Research Area
– Endocrinology
Solubility
– 10 mM in DMSO
Target
– Autophagy;CFTR
Pathway
– Autophagy;Membrane Transporter/Ion Channel
Product type
– Reference compound
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