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Isoprenaline (hydrochloride)
$30 – $40
Products Details
Product Description
– Isoprenaline (Isoproterenol) hydrochloride is a non-selective, orally active β-adrenergic receptor agonist. Isoprenaline has potent peripheral vasodilator, bronchodilator, and cardiac stimulating activities. Isoprenaline can be used for the research of bradycardia and bronchial asthma[1][2][3][4][5][6].
Web ID
– HY-B0468
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture and light)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C11H18ClNO3
Citations
– ACS Appl Mater Interfaces. 2023 Mar 29.|ACS Appl Mater Interfaces. 2023 Oct 4.|ACS Nano. 2023 Oct 18.|Biochem Biophys Res Commun. 7 January 2022.|Biofabrication. 2022 Oct 4.|Biomed Pharmacother. 2021 Apr 8;139:111562.|Biomed Pharmacother. 2021, 111531.|Biomolecules. 2022, 12(11), 1574.|bioRxiv. 2020 Jan.|Cell Biol Int. 2021 Jan;45(1):188-197.|Cell Cycle. 2021 Jun 7;1-17.|Cell Death Differ. 2022 Nov 3.|Cell Mol Immunol. 2023 Jan 5.|Cell Rep. 2022 Mar 8;38(10):110468.|Cell Rep. 2019 Dec 3;29(10):2929-2935.e4|Circulation. 2018 Jun 5;137(23):2497-2513.|Eur J Pharmacol. 2020 Nov 5;886:173439.|Eur J Pharmacol. 2021 Jun 23;907:174277.|FASEB J. 2022 Mar;36(3):e22219.|Food Chem Toxicol. 2023 Feb 17;113670.|Food Funct. 2018 Nov 14;9(11):5528-5535. |Front Oncol. 2021 Apr 22;11:665763.|Int Immunopharmacol. 2023 Sep 5;124(Pt A):110876.|iScience. 2023 Jul 19.|J Cardiovasc Transl Res. 2023 Jan 30.|J Exp Clin Cancer Res. 2019 Apr 25;38(1):174. |J Funct Foods. 66 (2020) 1038022.|J Tradit Complement Med. 2023 Jul 12.|Mbio. 2022 Nov 29;e0229722.|Nat Commun. 2020 Sep 25;11(1):4857.|Nat Prod Commun. 2023, 18(1): 1934578X221144581.|Naunyn Schmiedebergs Arch Pharmacol. 2018 Dec;391(12):1373-1385. |Pharmaceuticals. 2022, 15(1), 73.|Prostate. 2020 Nov;80(15):1328-1340.|Research Square Preprint. 2021 Jan.|Research Square Preprint. 2023 Sep 14.|Research Square Print. 2023 Feb 7.|Science. 2020 Dec 4;370(6521):eaay2002.|Biomed Res-TOKYO. 2023 Jun 1.|J Inflamm Res. 2023 Oct 24.|Nutrients. 2023 Mar 9.
References
– [1]Lei M, et al. Modulation of delayed rectifier potassium current, iK, by isoprenaline in rabbit isolated pacemaker cells. Exp Physiol. 2000 Jan;85(1):27-35.|[2]Degerman E, et al. Evidence that insulin and isoprenaline activate the cGMP-inhibited low-K<sub>m</sub> cAMP phosphodiesterase in rat fat cells by phosphorylation. Proc Natl Acad Sci U S A. 1990 Jan;87(2):533-7|[3]Vannucci SJ, et al. Cell surface accessibility of GLUT4 glucose transporters in insulin-stimulated rat adipose cells. Modulation by isoprenaline and adenosine. Biochem J. 1992 Nov 15;288 (Pt 1):325-30.|[4]Delpy E, et al. Effects of cyclic GMP elevation on isoprenaline-induced increase in cyclic AMP and relaxation in rat aortic smooth muscle: role of phosphodiesterase 3. Br J Pharmacol. 1996 Oct;119(3):471-8.|[5]Muller FU, et al. Isoprenaline stimulates gene transcription of the inhibitory G protein alpha-subunit Gi alpha-2 in rat heart. Circ Res. 1993 Mar;72(3):696-700.|[6]M E Conolly, et al. Metabolism of isoprenaline in dog and man. Br J Pharmacol
CAS Number
– 51-30-9
Molecular Weight
– 247.72
Compound Purity
– 99.73
SMILES
– OC1=CC=C(C(O)CNC(C)C)C=C1O.Cl
Clinical Information
– Launched
Research Area
– Cardiovascular Disease; Endocrinology
Solubility
– DMSO : 80 mg/mL (ultrasonic)|H2O : ≥ 50 mg/mL
Target
– Adrenergic Receptor;Endogenous Metabolite
Isoform
– β adrenergic receptor
Pathway
– GPCR/G Protein;Metabolic Enzyme/Protease;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
