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Products Details
Product Description
– IRAK4-IN-27 (Compound 22) is a potent, selective inhibitor of IRAK4, with IC50 of 8.7 nM. IRAK4-IN-27 inhibits cell growth, and promotes apoptosis in MYD88 L265P diffuse large B-cell lymphoma (DLBCL) cell line. IRAK4-IN-27 can be used for DLBCL study[1].
Web ID
– HY-155574
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C23H22N6O3
References
– [1]Chen Y, synthesis and pharmacological evaluation of 2,3-dihydrobenzofuran IRAK4 inhibitors for the treatment of diffuse large B-cell lymphoma. Eur J Med Chem. 2023;256:115453.
Molecular Weight
– 430.46
SMILES
– CN1C=CC(C2=CC3=C(CC(C)(O3)C)C=C2NC(C4=COC(C5=CC=NC(N)=C5)=N4)=O)=N1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;IRAK
Isoform
– IRAK4
Pathway
– Apoptosis;Immunology/Inflammation
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
