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Products Details
Product Description
– IRAK4-IN-12 (compound 37) is a potent IRAK4 inhibitor with an IC50 of 0.015 µM. IRAK4-IN-12 shows cell pIRAK4 potencies with an IC50 of 0.5 µM[1].
Web ID
– HY-146073
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C24H31FN8O
References
– [1]Cumming IA, et al. Identification and optimisation of a pyrimidopyridone series of IRAK4 inhibitors. Bioorg Med Chem. 2022 Jun 1;63:116729.
Molecular Weight
– 466.55
SMILES
– F[C@@H](CN1C=CC2=C(C(NC3(CC3)C)=NC(NC4=CN(N=C4)C5CC6(CN(C6)C)C5)=N2)C1=O)C
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– IRAK
Isoform
– IRAK4
Pathway
– Immunology/Inflammation
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
