Download Files:
INT-777 (R-enantiomer)
$420 – $840
Products Details
Product Description
– INT-777 (R-enantiomer) is the R-enantiomer of INT-777, with EC50 of 4.79 μM for TGR5, and less potent than INT-777.
Web ID
– HY-15677A
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Molecular Formula
– C27H46O5
References
– [1]Pellicciari R, et al. Discovery of 6alpha-ethyl-23(S)-methylcholic acid (S-EMCA, INT-777) as a potent and selective agonist for the TGR5 receptor, a novel target for diabesity. J Med Chem. 2009 Dec 24;52(24):7958-61.
CAS Number
– 1198786-98-9
Molecular Weight
– 450.65
Compound Purity
– 98.73
SMILES
– O[C@@H]1CC[C@@]2(C)[C@@]([C@@H](CC)[C@@H](O)[C@]3([H])[C@]2([H])C[C@H](O)[C@@]4(C)[C@@]3([H])CC[C@@H]4[C@H](C)C[C@@H](C)C(O)=O)([H])C1
Clinical Information
– No Development Reported
Research Area
– Others
Solubility
– DMSO : ≥ 100 mg/mL
Target
– G protein-coupled Bile Acid Receptor 1
Pathway
– GPCR/G Protein
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
