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Products Details
Product Description
– Inotilone is an inhibitor of matrix metalloproteinase MMP-2 and MMP-9, to against metastatic in lung cancer cells. Inotilone enhances the activity of the antioxidant enzymes to support its anti-metastatic activity. Inotilone also inhibits IκBα phosphorylation and NFκB p65 nuclear translocation, involving in FAK, PI3K/AKT, MAPKs and NFκB pathways[1].
Web ID
– HY-111172
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C12H10O4
References
– [1]Chao W, et al. Inotilone from Inonotus linteus suppresses lung cancer metastasis in vitro and in vivo through ROS-mediated PI3K/AKT/MAPK signaling pathways. Sci Rep. 2019 Feb 20;9(1):2344.
CAS Number
– 906366-79-8
Molecular Weight
– 218.21
SMILES
– O=C1/C(OC(C)=C1)=C/C2=CC=C(O)C(O)=C2
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– MMP;NF-κB
Pathway
– Metabolic Enzyme/Protease;NF-κB
Product type
– Reference compound
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