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Products Details
Product Description
– INF200 (compound 5) is a sulfonylurea-based inhibitor of NLRP3 and NLRP3-mediated pyroptosis. INF200 has beneficial cardiometabolic effects in rat model of high-fat diet (HFD)-induced metaflammation，and shows anti-inflammatory activity to (10 μM) decreases IL-1β release in human macrophages. INF200 improves glucose and lipid profiles，and attenuates systemic inflammation and biomarkers of cardiac dysfunction (particularly BNP). INF200 also improves myocardial damage-dependent ischemia/reperfusion injury (IRI) in hemodynamic evaluation[1].
Web ID
– HY-155517
Shipping
– Room temperature
Molecular Formula
– C13H13ClN2O4
References
– [1]Gastaldi S, et al. Discovery of a novel 1,3,4-oxadiazol-2-one-based NLRP3 inhibitor as a pharmacological agent to mitigate cardiac and metabolic complications in an experimental model of diet-induced metaflammation. Eur J Med Chem. 2023 Sep 5;257:115542.
Molecular Weight
– 296.71
SMILES
– ClC1=CC=CC=C1CC(O2)=NN(CC(OCC)=O)C2=O
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– NOD-like Receptor (NLR);Pyroptosis
Pathway
– Apoptosis;Immunology/Inflammation
Product type
– Reference compound
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