Inavolisib
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Inavolisib

SKU T15375-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 128 CAD through 3,808 CAD

Products Details

Product Description

– Inavolisib (GDC-0077) is an orally available selective PI3Kα inhibitor with an IC50 value of 0.038 nM.It exerts its activity by binding to the ATP-binding site of PI3K, thereby inhibiting the phosphorylation of PIP2 to PIP3.

Web ID

– T15375

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C18H19F2N5O4

References

– R Hong, Abstract PD4-14: GDC-0077 is a selective PI3Kalpha inhibitor that demonstrates robust efficacy in PIK3CA mutant breast cancer models as a single agent and in combination with standard of care therapies. 2017 San Antonio Breast Cancer Symposium.

CAS Number

– 2060571-02-8

Molecular Weight

– C18H19F2N5O4

Compound Purity

– 0.9987

SMILES

– C[C@H](Nc1ccc2-c3nc(cn3CCOc2c1)N1[C@@H](COC1=O)C(F)F)C(N)=O

Target

– Others

Pathway

– PI3K/Akt/mTOR signaling|||Apoptosis

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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