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Imiquimod (hydrochloride)
$60 – $137
Products Details
Product Description
– Imiquimod hydrochloride (R 837 hydrochloride), an immune response modifier, is a selective toll like receptor 7 (TLR7) agonist. Imiquimod hydrochloride exhibits antiviral and antitumor effects in vivo. Imiquimod hydrochloride can be used for the research of external genital, perianal warts, cancer and COVID-19[1][2].
Web ID
– HY-B0180A
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– COVID-19-anti-virus
Molecular Formula
– C14H17ClN4
Citations
– Int J Pharm. 2023 Nov 7:648:123583.|J Nanobiotechnology. 2023 Feb 10;21(1):50.|Nat Commun. 2022 Jul 22;13(1):4255.|Nucleic Acids Res. 2021 Jan 8;49(D1):D1113-D1121.|Virulence. 2023 Dec;14(1):2223394.|ACS Appl Bio Mater. 2019, 2, 874-883.|Am J Respir Cell Mol Biol. 2022 Oct 13.|Biomaterials. 2021, 120724.|Biomaterials. 2022 Feb 14;282:121411.|Cell Commun Signal. 2023 Aug 18;21(1):215.|Cell Rep. 2021 Feb 2;34(5):108724.|Diam Relat Mater. 2023 May 26, 110058.|Drug Deliv. 2023 Dec;30(1):2183814.|EMBO Rep. 2022 Feb 3;23(2):e53499.|FEBS Lett. 2021 Aug 13.|J Control Release. 2023 Aug 12;361:443-454.|J Invest Dermatol. 2021 Oct 20;S0022-202X(21)02369-1.|J Nanobiotechnology. 2022 May 14;20(1):228.|MedComm. 04 March 2022.|Nat Commun. 2016 May 25;7:11724. |Nucleic Acids Res. 2021 Jan 8;49(D1):D1113-D1121.|Oxid Med Cell Longev. 12 Oct 2022.|Research Square Preprint. 2021 Oct.|Research Square Preprint. 2023 Nov 17.|Research Square Print. 2023 Feb 1.|Theranostics. 2023 Apr 9;13(7):2226-2240.|Nucleic Acids Res. 2021 Jan 8;49(D1):D1113-D1121.|Pharmacol Res. 2023 Nov 24:198:107016.
References
– [1]Michael P Schön, et al. The small antitumoral immune response modifier imiquimod interacts with adenosine receptor signaling in a TLR7- and TLR8-independent fashion. J Invest Dermatol. 2006 Jun;126(6):1338-47.|[2]Aditya K Gupta, et al. Imiquimod: a review. J Cutan Med Surg. Nov-Dec 2002;6(6):554-60.|[3]Yuji Kan, et al. Imiquimod suppresses propagation of herpes simplex virus 1 by upregulation of cystatin A via the adenosine receptor A1 pathway. J Virol. 2012 Oct;86(19):10338-46.|[4]Athina Angelopoulou, et al. Imiquimod – A toll like receptor 7 agonist – Is an ideal option for management of COVID 19. Environ Res. 2020 Sep; 188: 109858.
CAS Number
– 99011-78-6
Molecular Weight
– 276.76
Compound Purity
– 99.80
SMILES
– NC1=NC2=CC=CC=C2C3=C1N=CN3CC(C)C.Cl
Clinical Information
– Launched
Research Area
– Cancer; Infection; Inflammation/Immunology
Solubility
– DMSO : 8 mg/mL (ultrasonic;warming;heat to 50°C)|Ethanol : 3.85 mg/mL (ultrasonic)|H2O : 4.8 mg/mL (ultrasonic)|Methanol : 24 mg/mL (ultrasonic)
Target
– Autophagy;HSV;SARS-CoV;Toll-like Receptor (TLR)
Isoform
– HSV-1;TLR7
Pathway
– Anti-infection;Autophagy;Immunology/Inflammation
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
