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Imipramine
Price range: 83 CAD through 1,549 CAD
Products Details
Product Description
– Imipramine (Dimipressin) is an orally active Fascin1 inhibitor with antidepressant and antitumor activity.Imipramine inhibits the 5-hydroxytryptamine transporter (IC50: 32 nM), induces apoptosis, and induces autophagy in U-87MG glioma cells.Imipramine has neuroprotective and immunomodulatory activities, inhibits TNT, and is used to label brain blood vessels.Imipramine is a neuroprotective and immunomodulatory compound. Imipramine has neuroprotective and immunomodulatory activities, inhibits invasion and migration of TNBC cells, and can be used to study breast cancer and epilepsy.
Web ID
– T20025
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C19H24N2
Citations
– 1. Wang Y, Wang X, Wang X, et al. Imipramine impedes glioma progression by inhibiting YAP as a Hippo pathway independent manner and synergizes with temozolomide. Journal of Cellular and Molecular Medicine. 2021
2. Wang Y J, Liu L, Wang Y, et al. Imipramine exerts antidepressant-like effects in chronic stress models of depression by promoting CRTC1 expression in the mPFC. Brain Research Bulletin. 2020, 164: 257-268.
References
– Alburquerque-González B, et al. New role of the antidepressant imipramine as a Fascin1 inhibitor in colorectal cancer cells. Exp Mol Med. 2020 Feb;52(2):281-292.
CAS Number
– 50-49-7
Molecular Weight
– C19H24N2
Compound Purity
– 0.994
SMILES
– C=1C=CC2=C(C1)N(C=3C=CC=CC3CC2)CCCN(C)C
Target
– Others
Pathway
– Apoptosis
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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