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ILS-920
Products Details
Product Description
– ILS-920 is a nonimmunosuppressive Rapamycin analog with reduced immunosuppressive activity and potent neuroprotective activity. ILS-920 binds selectively to the immunophilin FKBP52 and to the β1-subunit of L-type voltage-gated calcium channels (VGCC). ILS-920 shows 200-fold selectivity for FKBP52 versus FKBP12[1].
Web ID
– HY-106345
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C57H86N2O14
References
– [1]Ruan B, et al. Binding of rapamycin analogs to calcium channels and FKBP52 contributes to their neuroprotective activities. Proc Natl Acad Sci U S A. 2008 Jan 8;105(1):33-8.
CAS Number
– 892494-07-4
Molecular Weight
– 1023.30
SMILES
– O[C@H]1[C@H](OC)C[C@H](C[C@@H](C)[C@@H](OC([C@@H]2CCCCN2C(C([C@@]3(O)[C@H](C)CC[C@@H](C[C@H](OC)/C(C)=C/[C@@H]4ON(C5=CC=CC=C5)[C@H]([C@H](C[C@H]6C)C)CC4)O3)=O)=O)=O)CC([C@H](C)/C=C(C)/[C@@H](O)[C@@H](OC)C6=O)=O)CC1
Clinical Information
– Phase 1
Research Area
– Inflammation/Immunology; Neurological Disease
Solubility
– 10 mM in DMSO
Target
– Calcium Channel;FKBP
Isoform
– L-type calcium channel
Pathway
– Apoptosis;Autophagy;Immunology/Inflammation;Membrane Transporter/Ion Channel;Neuronal Signaling
Product type
– Reference compound
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