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Products Details
Product Description
– IGF2BP1-IN-1 (Compound A11) is a IGF2BP1 inhibitor and inhibits downstream signaling. IGF2BP1-IN-1 binds to IGF2BP1 protein with a KD value of 2.88 nM. IGF2BP1-IN-1 inhibits cancer cells proliferation (IC50: 9 nM for A549 cell, 34 nM for HCT116). IGF2BP1-IN-1 induces cancer cell apoptosis. GF2BP1-IN-1 inhibits tumor growth in A549 xenograft mouse model[1].
Web ID
– HY-156110
Shipping
– Room temperature
Molecular Formula
– C42H52FN3O10
References
– [1]Shang FF, et al. Discovery of Triazolyl Derivatives of Cucurbitacin B Targeting IGF2BP1 against Non-Small Cell Lung Cancer. J Med Chem. 2023 Sep 8.
Molecular Weight
– 777.87
SMILES
– O=C1N(N=CN1C2=CC=C(C=C2)F)CC(O[C@@H]3C(C(C)(C)C4=CC[C@]([H])([C@@]5([C@@]4(C3)[H])C)[C@@](C)([C@@]6(CC5=O)C)C[C@H](C6[C@](C)(C(/C=C/C(C)(OC(C)=O)C)=O)O)O)=O)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Insulin Receptor
Pathway
– Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
