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Products Details
Product Description
– IGF2BP1-IN-1 (Compound A11) is a IGF2BP1 inhibitor and inhibits downstream signaling. IGF2BP1-IN-1 binds to IGF2BP1 protein with a KD value of 2.88 nM. IGF2BP1-IN-1 inhibits cancer cells proliferation (IC50: 9 nM for A549 cell, 34 nM for HCT116). IGF2BP1-IN-1 induces cancer cell apoptosis. GF2BP1-IN-1 inhibits tumor growth in A549 xenograft mouse model[1].
Web ID
– HY-156110
Shipping
– Room temperature
Molecular Formula
– C42H52FN3O10
References
– [1]Shang FF, et al. Discovery of Triazolyl Derivatives of Cucurbitacin B Targeting IGF2BP1 against Non-Small Cell Lung Cancer. J Med Chem. 2023 Sep 8.
Molecular Weight
– 777.87
SMILES
– O=C1N(N=CN1C2=CC=C(C=C2)F)CC(O[C@@H]3C(C(C)(C)C4=CC[C@]([H])([C@@]5([C@@]4(C3)[H])C)[C@@](C)([C@@]6(CC5=O)C)C[C@H](C6[C@](C)(C(/C=C/C(C)(OC(C)=O)C)=O)O)O)=O)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Insulin Receptor
Pathway
– Protein Tyrosine Kinase/RTK
Product type
– Reference compound
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