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Products Details
Product Description
– IDO1-IN-2 (compound 16) is a potent and selective IDO1 inhibitor with IC50s of 81 nM, 59 nM (mouse) and 28 nM (rat), respectively. IDO1-IN-2 has anti-cancer activity[1].
Web ID
– HY-130607
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C15H17FN6O4
References
– [1]Zhang H, et al.Discovery of Amino-cyclobutarene-derived Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitors for Cancer Immunotherapy.ACS Med Chem Lett. 2019 Sep 18;10(11):1530-1536.
CAS Number
– 2346614-58-0
Molecular Weight
– 364.33
SMILES
– O/N=C(N[C@H]1CC2=C1C=C(F)C=C2)/C3=NON=C3NCC(NCCO)=O
Clinical Information
– No Development Reported
Research Area
– Cancer; Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Indoleamine 2,3-Dioxygenase (IDO)
Isoform
– IDO1
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
