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Products Details
Product Description
– ICMT-IN-54 (compound 7c) is an adamantyl analogue and an ICMT inhibitor (IC50=12.4 μM), which can inhibit ICMT Methylation. ICMT-in-54 inhibits BFC (N-biotinyl-(6-aminohexanoic)-S-farnesyl-L-cysteine) methylation in saccharomyces cerevisiae expressing ICMT, which is an indirect effect of inhibiting ICMT methylation[1].
Web ID
– HY-149730
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C29H45NO3S
References
– [1]Donelson JL, et al. Amide-substituted farnesylcysteine analogs as inhibitors of human isoprenylcysteine carboxyl methyltransferase. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4420-3.
CAS Number
– 908856-14-4
Molecular Weight
– 487.74
SMILES
– C/C(C)=C/CC/C(C)=C/CC/C(C)=C/CSC[C@@H](C(O)=O)NC(C12CC3CC(CC(C3)C2)C1)=O
Clinical Information
– No Development Reported
Research Area
– cancer
Solubility
– 10 mM in DMSO
Target
– ICMT
Pathway
– GPCR/G Protein
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
