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Homoharringtonine
Price range: 80 CAD through 501 CAD
Products Details
Product Description
– Homoharringtonine (HHT) is a natural alkaloid that inhibits the translation of proteins and is cytotoxic. Homoharringtonine acts on the ribosomes of tumor cells to inhibit the elongation step of protein translation, thereby inhibiting protein synthesis, and has antitumor activity.
Web ID
– T3380
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C29H39NO9
Citations
– 1. Wang F, Xie M, Chen P, et al. Homoharringtonine combined with cladribine and aclarubicin (HCA) in acute myeloid leukemia: A new regimen of conventional drugs and its mechanism. Oxidative Medicine and Cellular Longevity. 2022
2. Qiu X, Zhang H, Tang Z, et al.Homoharringtonine promotes heart allograft acceptance by enhancing regulatory T cells induction in a mouse model.Chinese Medical Journal.2023: 10.1097.
3. Zou C, Li W, Zhang Y, et al.Identification of an anaplastic subtype of prostate cancer amenable to therapies targeting SP1 or translation elongation.Science Advances.2024, 10(14): eadm7098.
References
– Cao W, et al. Homoharringtonine induces apoptosis and inhibits STAT3 via IL-6/JAK1/STAT3 signal pathway in Gefitinib-resistant lung cancer cells. Sci Rep. 2015 Jul 13;5:8477.
CAS Number
– 26833-87-4
Molecular Weight
– C29H39NO9
Compound Purity
– 0.9859
SMILES
– COC(=O)CC(O)(CCCC(C)(C)O)C(=O)OC1C2c3cc4OCOc4cc3CCN3CCCC23C=C1OC
Pathway
– JAK/STAT signaling|||Stem Cells
Product type
– Natural Product
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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