Download Files:
Products Details
Product Description
– HLI98C is a ubiquitin ligase inhibitor. HLI98C inhibits p53 ubiquitylation. HLI98C inhibits HDM2 auto-ubiquitylation[1].
Web ID
– HY-18327
Shipping
– Room temperature
Molecular Formula
– C17H9ClN4O4
References
– [1]Yang Y, et al. Small molecule inhibitors of HDM2 ubiquitin ligase activity stabilize and activate p53 in cells. Cancer Cell. 2005 Jun;7(6):547-59.
CAS Number
– 317326-90-2
Molecular Weight
– 368.73
SMILES
– O=C(C1=CC2=CC([N+]([O-])=O)=CC=C2N(C3=CC=CC(Cl)=C3)C1=N4)NC4=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– E1/E2/E3 Enzyme;MDM-2/p53
Pathway
– Apoptosis;Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
