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HJC0197
$110 – $825
Products Details
Product Description
– HJC0197 is a potent Epac1 (exchange protein directly activated by cAMP 1) and Epac2 (IC50=5.9 μM for Epac2) antagonist. HJC0197 selectively blocks cAMP-induced Epac activation. HJC0197 inhibits Epac1-mediated Rap1-GDP exchange activity at 25 μM in the presence of equal concentration of cAMP[1].
Web ID
– HY-117958
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C19H21N3OS
References
– [1]Chen H, et al. 5-Cyano-6-oxo-1,6-dihydro-pyrimidines as potent antagonists targeting exchange proteins directly activated by cAMP. Bioorg Med Chem Lett. 2012 Jun 15;22(12):4038-43.
CAS Number
– 1383539-73-8
Molecular Weight
– 339.45
Compound Purity
– 99.58
SMILES
– N#CC1=C(C2CCCC2)N=C(SCC3=CC(C)=CC=C3C)NC1=O
Clinical Information
– No Development Reported
Research Area
– Cancer; Metabolic Disease; Cardiovascular Disease
Solubility
– DMSO : 50 mg/mL (ultrasonic)|H2O : ≥ 1.67 mg/mL
Target
– Ras
Pathway
– GPCR/G Protein
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
