Products Details

Product Description

– HF50731 (compound 21) is a potent CXCR4 antagonist. HF50731 shows strong CXCR4 binding affinity, with IC50 of 19.8 nM. HF50731 effectively inhibits calcium mobilization, cell migration, and HIV-1 infection via CXCR4 coreceptor, with IC50 values of 119.2 nM, 621.4 nM and 1.5 μM[1].

Web ID

– HY-146413

Shipping

– Room temperature

Applications

– COVID-19-anti-virus

Molecular Formula

– C26H46N4

References

– [1]Fang X, Meng Q, Zhang H, Liang B, Zhu S, Wang J, Zhang C, Huang LS, Zhang X, Schooley RT, An J, Xu Y, Huang Z. Design, synthesis, and biological characterization of a new class of symmetrical polyamine-based small molecule CXCR4 antagonists. Eur J Med Chem. 2020 Aug 15;200:112410.

CAS Number

– 2484771-19-7

Molecular Weight

– 414.67

SMILES

– C1(CNCCCNC2CCCCC2)=CC=C(CNCCCNC3CCCCC3)C=C1

Clinical Information

– No Development Reported

Research Area

– Cancer; Infection

Solubility

– 10 mM in DMSO

Target

– CXCR;HIV

Isoform

– CXCR4;HIV-1

Pathway

– Anti-infection;GPCR/G Protein;Immunology/Inflammation

Product type

– Reference compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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