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Products Details
Product Description
– HDAC6/HSP90-IN-1 (compound 17) is a potent and selective dual inhibitor of HDAC6 and HSP90, with IC50 values of 4.3 and 46.8 nM, respectively. HDAC6/HSP90-IN-1 down-regulates PD-L1 expression in INF-γ treated H1975 lung cancer cells. HDAC6/HSP90-IN-1 inhibits tumor growth in human H1975 xenograft mice[1].
Web ID
– HY-146293
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C28H37N3O6
References
– [1]Ojha R, et al. Isoindoline scaffold-based dual inhibitors of HDAC6 and HSP90 suppressing the growth of lung cancer in vitro and in vivo. Eur J Med Chem. 2020 Mar 15;190:112086.
CAS Number
– 2411955-43-4
Molecular Weight
– 511.61
SMILES
– CC(C1=C(C=C(C(C(N2CC3=CC=C(C=C3C2)NC(CCCCCCCCC(NO)=O)=O)=O)=C1)O)O)C
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– HDAC;HSP
Isoform
– HDAC1;HDAC3;HDAC6;HDAC8;HSP90
Pathway
– Cell Cycle/DNA Damage;Epigenetics;Metabolic Enzyme/Protease
Product type
– Reference compound
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