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HDAC3-IN-T247

$250$1,950

Products Details

Product Description

– HDAC3-IN-T247 is a potent and selective HDAC3 (histone deacetylase 3) inhibitor, with an IC50 of 0.24 µM. HDAC3-IN-T247 induces a selective increase of NF-κB acetylation in HCT116 cells. HDAC3-IN-T247 shows anticancer and antiviral activity. HDAC3-IN-T247 inhibits growth of cancer cells, and activates HIV gene expression in latent HIV-infected cells[1].

Web ID

– HY-123295

Storage Temperature

– -20°C, 3 years; 4°C, 2 years (Powder)

Shipping

– Room Temperature

Applications

– COVID-19-anti-virus

Molecular Formula

– C21H19N5OS

References

– [1]Suzuki T, et al. Identification of highly selective and potent histone deacetylase 3 inhibitors using click chemistry-based combinatorial fragment assembly. PLoS One. 2013 Jul 16;8(7):e68669.

CAS Number

– 1451042-18-4

Molecular Weight

– 389.47

Compound Purity

– 98.94

SMILES

– O=C(C1=CC=C(C2=CN(CCC3=CSC=C3)N=N2)C=C1)NC4=C(N)C=CC=C4

Clinical Information

– No Development Reported

Research Area

– Cancer; Infection

Solubility

– DMSO : 25 mg/mL (ultrasonic)

Target

– HDAC

Isoform

– HDAC1;HDAC3;HDAC4;HDAC6;HDAC8

Pathway

– Cell Cycle/DNA Damage;Epigenetics

Product type

– Reference compound

Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.

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