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Products Details
Product Description
– hCAIX/XII-IN-5 (Coumarin 9a) a carbonic anhydrase (CA) inhibitor, and exhibits excellent hCA IX/XII selectivity (Ki=93.9 and 85.7 nM, respectively) over hCA I and hCA II. hCAIX/XII-IN-5 shows anti-proliferative activities to cancer cells. hCAIX/XII-IN-5 can delay cell cycle and induce apoptosis[1].
Web ID
– HY-150695
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C18H13NO3
References
– [1]Hany S Ibrahim Insights into the effect of elaborating coumarin-based aryl enaminones with sulfonamide or carboxylic acid functionality on carbonic anhydrase inhibitory potency and selectivity. Bioorg Chem. 2022 Sep;126:105888.
CAS Number
– 2421127-99-1
Molecular Weight
– 291.30
SMILES
– O=C1C(C(/C=C/NC2=CC=CC=C2)=O)=CC3=C(O1)C=CC=C3
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Carbonic Anhydrase
Isoform
– CA â…¨;CA XII
Pathway
– Apoptosis;Metabolic Enzyme/Protease
Product type
– Reference compound
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