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Products Details
Product Description
– hCAIX-IN-8 (compound 7i) is a potent and selective hCAIX inhibitor with IC50s of 1.99, 0.024, 1.10 µM for CAII, CAIX, CAVA respectively. hCAIX-IN-8 shows anti-proliferation activity with low toxicity. hCAIX-IN-8 decreases the epithelial to mesenchymal transitions and induces apoptosis. hCAIX-IN-8 inhibits cell migration and colonization potential[1].
Web ID
– HY-147722
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C19H16N4O6
References
– [1]Aneja B,et al. Design, synthesis & biological evaluation of ferulic acid-based small molecule inhibitors against tumor-associated carbonic anhydrase IX. Bioorg Med Chem. 2020 May 1;28(9):115424.
CAS Number
– 2414633-40-0
Molecular Weight
– 396.35
SMILES
– COC1=CC(/C=C/C(O)=O)=CC=C1OCC2=CN(N=N2)C3=CC([N+]([O-])=O)=CC=C3
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Carbonic Anhydrase
Isoform
– CA Ⅸ
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
